Suck it and see really, however if the application actually uses the GPU to make the application faster, then physical is the only way to go.
Just because the images are large, it doesnt always mean the GPU is involved, it may just need beefy CPUs. Saying that though I would avoid virtualising things like this as throwing 300MB images around will take a lot of memory bandwidth which a virtualised machine may not be able to provide.
Jen
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